Improved spatial resolution in the imaging of biological tissue using desorption electrospray ionization.

@article{Campbell2012ImprovedSR,
  title={Improved spatial resolution in the imaging of biological tissue using desorption electrospray ionization.},
  author={Dahlia I Campbell and Christina R Ferreira and Livia S Eberlin and R Graham Cooks},
  journal={Analytical and bioanalytical chemistry},
  year={2012},
  volume={404 2},
  pages={389-98}
}
Desorption electrospray ionization imaging allows biomarker discovery and disease diagnosis through chemical characterization of biological samples in their native environment. Optimization of experimental parameters including emitter capillary size, solvent composition, solvent flow rate, mass spectrometry scan-rate and step-size is shown here to improve the resolution available in the study of biological tissue from 180 μm to about 35 μm using an unmodified commercial mass spectrometer. Mouse… CONTINUE READING