Improved solid-phase peptide synthesis method utilizing alpha-azide-protected amino acids.

@article{Lundquist2001ImprovedSP,
  title={Improved solid-phase peptide synthesis method utilizing alpha-azide-protected amino acids.},
  author={Joseph T Lundquist and Jeffrey C. Pelletier},
  journal={Organic letters},
  year={2001},
  volume={3 5},
  pages={781-3}
}
[structure: see text]. Pure alpha-azido acids were prepared using an efficient diazo transfer method followed by buffered workup. These building blocks were used to prepare small peptides on Wang resin by two approaches. Peptides prone to diketopiperazine formation were prepared in good yields by coupling acids to resin bound iminophosphoranes during Fmoc… CONTINUE READING