Improved reproducibility of the 'large-window' method of assessing transcapillary and interstitial fluorescein diffusion in the skin in healthy subjects and in subjects with insulin-dependent diabetes mellitus.

@article{Jager1997ImprovedRO,
  title={Improved reproducibility of the 'large-window' method of assessing transcapillary and interstitial fluorescein diffusion in the skin in healthy subjects and in subjects with insulin-dependent diabetes mellitus.},
  author={Jos Jager and Peter H N Oomen and Wim J. Sluiter and W. D. Reitsma and Andries J. Smit},
  journal={International journal of microcirculation, clinical and experimental},
  year={1997},
  volume={17 3},
  pages={150-8}
}
The transcapillary and interstitial diffusion of intravenously administered sodium fluorescein is used as a marker for capillary permeability. Fluorescein diffusion has been expressed by different parameters with reported coefficients of variation of 14-20%. Aim of the present study is to select a parameter which combines excellent reproducibility with the potential for discriminating insulin-dependent diabetic patients from healthy subjects. We performed three experiments to assess day-to-day… CONTINUE READING

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