Improved reproducibility in genome-wide DNA methylation analysis for PAXgene-fixed samples compared with restored formalin-fixed and paraffin-embedded DNA.

@article{Andersen2015ImprovedRI,
  title={Improved reproducibility in genome-wide DNA methylation analysis for PAXgene-fixed samples compared with restored formalin-fixed and paraffin-embedded DNA.},
  author={Gitte Brinch Andersen and H. E. Hager and Lise Lotte Hansen and J{\"o}rg Tost},
  journal={Analytical biochemistry},
  year={2015},
  volume={468},
  pages={50-8}
}
Formalin fixation has been the standard method for conservation of clinical specimens for decades. However, a major drawback is the high degradation of nucleic acids, which complicates its use in genome-wide analyses. Unbiased identification of biomarkers, however, requires genome-wide studies, precluding the use of the valuable archives of specimens with long-term follow-up data. Therefore, restoration protocols for DNA from formalin-fixed and paraffin-embedded (FFPE) samples have been… CONTINUE READING
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