Improved regional selectivity of hepatic arterial BCNU with degradable microspheres.

@article{Dakhil1982ImprovedRS,
  title={Improved regional selectivity of hepatic arterial BCNU with degradable microspheres.},
  author={Shaker R. Dakhil and William D. Ensminger and Kyoung-Sik Cho and John E. Niederhuber and Kim Doan and Richard Wheeler},
  journal={Cancer},
  year={1982},
  volume={50 4},
  pages={631-5}
}
Starch microspheres 40 micrometers in diameter, which are rapidly degraded by serum amylase, have been administered through hepatic arterial catheters to five patients with primary and metastatic liver cancer to determine whether (1) arterial blood flow through the liver could be temporarily blocked, and (2) such occlusion at the level of the arteriolar capillary bed would enhance regional uptake and catabolism and decrease systemic exposure to simultaneously administered hepatic arterial… CONTINUE READING