Improved protection from primary ocular HSV-1 infection and establishment of latency using multigenic DNA vaccines.

@article{Osorio2004ImprovedPF,
  title={Improved protection from primary ocular HSV-1 infection and establishment of latency using multigenic DNA vaccines.},
  author={Yanira Osorio and Jacob Cohen and Homayon Ghiasi},
  journal={Investigative ophthalmology & visual science},
  year={2004},
  volume={45 2},
  pages={506-14}
}
PURPOSE To compare the effectiveness of immunization with "naked" DNA corresponding to the genes encoding five HSV-1 glycoproteins, gB, gC, gD, gE, and gI (5gP DNA), with immunization with the five glycoproteins (5gP protein). Also, to compare immunization of 5gP protein in Montanide ISA 720 (SEPPIC, Paris, France), an adjuvant recently approved for use in humans, with immunization of 5gP protein in Freund's adjuvant. METHODS BALB/c mice were vaccinated with 5gP DNA or 5gP protein emulsified… CONTINUE READING

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