Improved prognosis with intensive treatment of children with cranial soft tissue sarcomas arising in nonorbital parameningeal sites. A report from the intergroup rhabdomyosarcoma study

@article{Raney1987ImprovedPW,
  title={Improved prognosis with intensive treatment of children with cranial soft tissue sarcomas arising in nonorbital parameningeal sites. A report from the intergroup rhabdomyosarcoma study},
  author={Richard Beverly Raney and Melvin Tefft and William A. Newton and Abdelsalam H. Ragab and Walter Lawrence and Edmund A. Gehan and Harold M. Maurer},
  journal={Cancer},
  year={1987},
  volume={59}
}
In the first Intergroup Rhabdomyosarcoma Study (IRS‐I), it was found that, of 57 patients with nonorbital cranial parameningeal sarcoma treated from 1972 to 1976, 20 patients (35%) developed meningeal sarcoma and 90% (18/20) died of this complication. Since about half of these 20 patients had received inadequate radiation therapy and all had radiation therapy delayed until week 6, the treatment program was modified in December 1977 to begin radiation therapy on day 0 to the entire neuraxis and… 
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TLDR
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TLDR
The overall survival rate was 96% and the eye was preserved in 86% of the patients, but vision was impaired in 70% of them, and the current IRS-V study recommends decreasing the dose of irradiation and using conformal techniques in an attempt to minimize these complications.
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Long-term effects in children treated with radiotherapy for head and neck rhabdomyosarcoma.
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