Improved procedure for the high-performance liquid chromatographic determination of valproic acid in serum as its phenacyl ester.

@article{Nakamura1984ImprovedPF,
  title={Improved procedure for the high-performance liquid chromatographic determination of valproic acid in serum as its phenacyl ester.},
  author={M. Nakamura and Koichi Kondo and Ryota Nishioka and Satoshi Kawai},
  journal={Journal of chromatography},
  year={1984},
  volume={310 2},
  pages={
          450-4
        }
}
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26 Citations
Background Citations
1
Methods Citations
1

26 Citations

A new derivatization method for the determination of valproic acid in serum using tetramethylammonium hydroxide as a catalyst.

A novel and high conversion-rate derivatization method has been developed and validated for the determination of VPA in human serum and can be applied to the analysis of V PA in clinic serum samples.

A simple and sensitive methodology for voltammetric determination of valproic acid in human blood plasma samples using 3-aminopropyletriethoxy silane coated magnetic nanoparticles modified pencil graphite electrode.

Valproic acid analysis by mass spectrometry part I: enhanced determination of valproic acid by microwave assisted chemical labeling

A simple method of using a microwave assisted derivatization procedure for improved detection and monitoring of VA derivatives by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS).

Derivatization oriented strategy for enhanced detection of valproic acid and its metabolites in human plasma and detection of valproic acid induced reactive oxygen species associated protein modifications by mass spectrometry.

HPLC DETERMINATION OF VALPROIC ACID IN PLASMA BY CONJUGATION TO A HYDRAZIDE

We developed a method to measure plasma levels of valproic acid (VA) using pre-column conjugation of VA to the fluorescent probe, 7-diethylaminocoumarin-3-carboxylic acid, hydrazide (DCCH). Swine…

Development and validation of an LC/MS/MS method for determination of valproic acid and its metabolite 2-propyl-4-pentenoic acid in monkey plasma

A rapid, accurate, and sensitive liquid chromatography/mass spectrometry (MS)/MS method for the quantitative determination of valproic acid (VPA) and its metabolite, 2-propyl-4-pentenoic acid (4-ene…

Determination of free and total valproic acid in human plasma by capillary electrophoresis with contactless conductivity detection.

An UPLC-MS/MS method for the determination of valproic acid in blood of a fatal intoxication case.

Quantitation of valproic acid in pharmaceutical preparations using dispersive liquid-liquid microextraction followed by gas chromatography-flame ionization detection without prior derivatization.

Dispersive liquid-liquid microextraction (DLLME), coupled with gas chromatography-flame ionization detection (GC-FID), has been successfully used for the extraction and determination of valproic acid…

A validated stability-indicating gas chromatography method for determination of divalproex sodium impurities in pharmaceutical preparation.

A stability-indicating gas chromatography method has been developed and validated for the quantitative determination of divalproex sodium impurities in pharmaceutical preparation and results indicate that the method is specific, accurate, linear, reproducible, rugged, and robust.

4 References

Phenacyl esters of fatty acids via crown ether catalysts for enhanced ultraviolet detection in liquid chromatography.

Valproic acid in plasma, as determined by liquid chromatography.

Monitoring serum valproic acid by gas chromatography with electron-capture detection.

  • S. Chan
  • Biology
    Clinical chemistry
  • 1980
This procedure to monitor, by gas chromatography with electron-capture detection, the concentration of valproic acid in serum is developed, and the peak-height ratio of phenacyl valproate to Phenacyl octanoate is linearly related to concentration up to 200 mg of valProic acid per liter.

Measurement of valproic acid in serum as the 4-bromophenacyl ester by high performance liquid chromatography.

  • J. MoodyS. Allan
  • Chemistry
    Clinica chimica acta; international journal of clinical chemistry
  • 1983