Improved prediction of signal peptides: SignalP 3.0.

  title={Improved prediction of signal peptides: SignalP 3.0.},
  author={Jannick Dyrl\ov Bendtsen and Henrik Nielsen and Gunnar von Heijne and S\oren Brunak},
  journal={Journal of molecular biology},
  volume={340 4},
We describe improvements of the currently most popular method for prediction of classically secreted proteins, SignalP. SignalP consists of two different predictors based on neural network and hidden Markov model algorithms, where both components have been updated. Motivated by the idea that the cleavage site position and the amino acid composition of the signal peptide are correlated, new features have been included as input to the neural network. This addition, combined with a thorough error… CONTINUE READING
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