Improved post-myocardial infarction survival with probucol in rats: effects on left ventricular function, morphology, cardiac oxidative stress and cytokine expression.

@article{Sia2002ImprovedPI,
  title={Improved post-myocardial infarction survival with probucol in rats: effects on left ventricular function, morphology, cardiac oxidative stress and cytokine expression.},
  author={Ying Tung Sia and Thomas G. Parker and Peter C. Liu and James N. Tsoporis and Albert Adam and Jean L. Rouleau},
  journal={Journal of the American College of Cardiology},
  year={2002},
  volume={39 1},
  pages={
          148-56
        }
}
OBJECTIVES The goal of this study was to evaluate whether reducing the potentially deleterious effects of oxidative stress with the potent anti-oxidant probucol improves prognosis after myocardial infarction (MI) in rats. BACKGROUND Oxidative stress has been documented in patients early and late after MI, particularly when it is associated with congestive heart failure. METHODS Rats surviving acute MIs for 24 h (n = 247) were assigned to vehicle or probucol (61 mg/kg, daily) for four weeks… CONTINUE READING

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