Improved polymerase ribozyme efficiency on hydrophobic assemblies.

  title={Improved polymerase ribozyme efficiency on hydrophobic assemblies.},
  author={Ulrich F M{\"u}ller and David P. Bartel},
  volume={14 3},
During an early step in the evolution of life, RNA served both as genome and as catalyst, according to the RNA world hypothesis. For self-replication, the RNA organisms must have contained an RNA that catalyzes RNA polymerization. As a first step toward recapitulating an RNA world in the laboratory, a polymerase ribozyme was generated previously by in vitro evolution and design. However, the efficiency of this ribozyme is about 100-fold too low for self-replication because of a low affinity of… CONTINUE READING
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