Improved polymerase ribozyme efficiency on hydrophobic assemblies.

@article{Mller2008ImprovedPR,
  title={Improved polymerase ribozyme efficiency on hydrophobic assemblies.},
  author={Ulrich F M{\"u}ller and David P. Bartel},
  journal={RNA},
  year={2008},
  volume={14 3},
  pages={552-62}
}
During an early step in the evolution of life, RNA served both as genome and as catalyst, according to the RNA world hypothesis. For self-replication, the RNA organisms must have contained an RNA that catalyzes RNA polymerization. As a first step toward recapitulating an RNA world in the laboratory, a polymerase ribozyme was generated previously by in vitro evolution and design. However, the efficiency of this ribozyme is about 100-fold too low for self-replication because of a low affinity of… CONTINUE READING
Highly Cited
This paper has 36 citations. REVIEW CITATIONS

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Selection of an improved

  • P. J. Unrau
  • RNA
  • 2007
Highly Influential
4 Excerpts

Micelle shape and size

  • T. Tanford
  • J . Phys . Chem .
  • 1972
Highly Influential
3 Excerpts

Metal chelates of adenosine triphosphate

  • M. M. T. Khan, A. E. Martell
  • J . Phys . Chem .
  • 1962
Highly Influential
1 Excerpt

Similar Papers

Loading similar papers…