Improved plating efficiencies for human tumors cloned in capillary tubes versus Petri dishes.

  title={Improved plating efficiencies for human tumors cloned in capillary tubes versus Petri dishes.},
  author={Daniel Von Hoff and B. J. Forseth and M Huong and J B Buchok and Bernd Lathan},
  journal={Cancer research},
  volume={46 8},
As now constituted, the human tumor cloning assay performed in Petri dishes has several limitations including: (a) not all patients' tumors form colonies in the assay; (b) the plating efficiencies (number of colonies formed/number of cells plated) are low; and (c) a large number of tumor cells are required to perform drug sensitivity testing. In this study the use of capillary tubes, as vessels in which to clone human tumors, is compared to the use of 35-mm Petri dishes. In 100-microliters… CONTINUE READING

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