Improved platelet survival after cold storage by prevention of glycoprotein Ibα clustering in lipid rafts.

@article{Gitz2012ImprovedPS,
  title={Improved platelet survival after cold storage by prevention of glycoprotein Ibα clustering in lipid rafts.},
  author={Eelo Gitz and Cornelis A. Koekman and Dave J van den Heuvel and Hans Deckmyn and Jan Willem N. Akkerman and Hans C. Gerritsen and Rolf T Urbanus},
  journal={Haematologica},
  year={2012},
  volume={97 12},
  pages={1873-81}
}
BACKGROUND Storing platelets for transfusion at room temperature increases the risk of microbial infection and decreases platelet functionality, leading to out-date discard rates of up to 20%. Cold storage may be a better alternative, but this treatment leads to rapid platelet clearance after transfusion, initiated by changes in glycoprotein Ibα, the receptor for von Willebrand factor. DESIGN AND METHODS We examined the change in glycoprotein Ibα distribution using Förster resonance energy… CONTINUE READING

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Platelet apoptosis by cold-induced glycoprotein Ibα clustering.

Journal of thrombosis and haemostasis : JTH • 2010
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