Improved permeability of acyclovir: optimization of mucoadhesive liposomes using the phospholipid vesicle-based permeation assay.

@article{Naderkhani2014ImprovedPO,
  title={Improved permeability of acyclovir: optimization of mucoadhesive liposomes using the phospholipid vesicle-based permeation assay.},
  author={Elenaz Naderkhani and Astrid Christine Erber and Nata{\vs}a {\vS}kalko-Basnet and G\oril Eide Flaten},
  journal={Journal of pharmaceutical sciences},
  year={2014},
  volume={103 2},
  pages={661-8}
}
The antiviral drug acyclovir (ACV) suffers from poor solubility both in lipophilic and hydrophilic environment, leading to low and highly variable bioavailability. To overcome these limitations, this study aimed at designing mucoadhesive ACV-containing liposomes to improve its permeability. Liposomes were prepared from egg phosphatidylcholine (E-PC) and E-PC/egg phosphatidylglycerol (E-PC/E-PG) and their surfaces coated with Carbopol. All liposomal formulations were fully characterized and for… CONTINUE READING