Improved pH measurements with a single PARACEST MRI contrast agent.

  title={Improved pH measurements with a single PARACEST MRI contrast agent.},
  author={Vipul R Sheth and Guanshu Liu and Yuguo Li and Mark D. Pagel},
  journal={Contrast media & molecular imaging},
  volume={7 1},
The measurement of extracellular pH has potential utility for assessing the therapeutic effects of pH-dependent and pH-altering therapies. A PARAmagnetic chemical exchange saturation transfer (PARACEST) MRI contrast agent, Yb-DO3A-oAA, has two CEST effects that are dependent on pH. A ratio derived from these CEST effects was linearly correlated with pH throughout the physiological pH range. The pH can be measured with a precision of 0.21 pH units and an accuracy of 0.09 pH units. The pH… CONTINUE READING

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