Improved oxytetracycline production in Streptomyces rimosus M4018 by metabolic engineering of the G6PDH gene in the pentose phosphate pathway.

@article{Tang2011ImprovedOP,
  title={Improved oxytetracycline production in Streptomyces rimosus M4018 by metabolic engineering of the G6PDH gene in the pentose phosphate pathway.},
  author={Zhenyu Tang and Ciying Xiao and Yingping Zhuang and Ju Chu and Siliang Zhang and Paul R Herron and Iain S. Hunter and Meijin Guo},
  journal={Enzyme and microbial technology},
  year={2011},
  volume={49 1},
  pages={17-24}
}
The aromatic polyketide antibiotic, oxytetracycline (OTC), is produced by Streptomyces rimosus as an important secondary metabolite. High level production of antibiotics in Streptomycetes requires precursors and cofactors which are derived from primary metabolism; therefore it is exigent to engineer the primary metabolism. This has been demonstrated by targeting a key enzyme in the oxidative pentose phosphate pathway (PPP) and nicotinamide adenine dinucleotide phosphate (NADPH) generation… CONTINUE READING
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