Improved outcome of patients older than 30 years receiving HLA-identical sibling hematopoietic stem cell transplantation for severe acquired aplastic anemia using fludarabine-based conditioning: a comparison with conventional conditioning regimen.

@article{Maury2009ImprovedOO,
  title={Improved outcome of patients older than 30 years receiving HLA-identical sibling hematopoietic stem cell transplantation for severe acquired aplastic anemia using fludarabine-based conditioning: a comparison with conventional conditioning regimen.},
  author={S{\'e}bastien Maury and Andrea Bacigalupo and Paolo N Anderlini and Mahmoud Deeb Aljurf and Judith Marsh and Gerard J Soci{\'e} and R. A. B. Oneto and Jakob Robert Passweg},
  journal={Haematologica},
  year={2009},
  volume={94 9},
  pages={1312-5}
}
Older age is a limitation for HLA-identical sibling hematopoietic stem cell transplantation (HSCT) as first-line therapy for severe acquired idiopathic aplastic anemia (SAA). Fludarabine (Flu)-based conditioning might improve outcome in older patients. We analyzed retrospectively 30 patients older than 30 years receiving such reduced-intensity conditioning HSCT according to recommendations of the European Group for Blood and Marrow Transplantation (EBMT) and compared their outcome to a control… CONTINUE READING
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Current concepts in the pathophysiology and treatment of aplastic ane

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