Improved outcome in haemophagocytic lymphohistiocytosis after bone marrow transplantation from related and unrelated donors: a single-centre experience of 12 patients.

@article{Duerken1999ImprovedOI,
  title={Improved outcome in haemophagocytic lymphohistiocytosis after bone marrow transplantation from related and unrelated donors: a single-centre experience of 12 patients.},
  author={Matthias Duerken and Martin Horstmann and Peter Bieling and Rudolf Erttmann and Hartmut Kabisch and C. C. L{\"o}liger and Edward M. Schneider and Hans Henning Hellwege and William R. Krueger and Nicholas M. Kroeger and Axel Rolf Zander and Gritta E. Janka},
  journal={British journal of haematology},
  year={1999},
  volume={106 4},
  pages={
          1052-8
        }
}
Haemophagocytic lymphohistiocytosis (HLH) is an autosomal recessive disease with histiocytic and lymphocytic infiltrations in multiple organs. Cure seems possible only by allogeneic bone marrow transplantation (BMT), but matched sibling donors (MSD) are restricted and high mortality rates are associated with BMT from unrelated donors (URD). We report on 12 consecutive HLH patients with an improved outcome following URD transplants. Eight patients received BMT from URD, four from MSD. Five… CONTINUE READING

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