Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes.

@article{Hsu2005ImprovedOI,
  title={Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes.},
  author={Katharine C Hsu and Carolyn A. Keever-Taylor and Andrew Wilton and Clara Pinto and Glenn Heller and Knarik Arkun and Richard J O'reilly and Mary M. Horowitz and B J Dupont},
  journal={Blood},
  year={2005},
  volume={105 12},
  pages={4878-84}
}
Inhibitory killer immunoglobulin (Ig)-like receptors (KIRs) recognize HLA-C and -B epitopes on target cells, thereby regulating natural killer (NK) cell activity. In 178 patients receiving T-cell-depleted HLA-identical sibling transplants for acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), acute lymphoblastic leukemia (ALL), or myelodysplastic syndrome (MDS), analysis of donor KIR genotype with HLA genotype demonstrated that 62.9% of the patients lacked an HLA ligand for… CONTINUE READING
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Expression of HLA-C-specific natural killer cell receptors MISSING KIR LIGAND IN HLA-IDENTICAL BMT

  • J Tanaka, A Mori, S Ohta
  • BLOOD,
  • 2005

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