Improved nonparametric estimation of the optimal diagnostic cut-off point associated with the Youden index under different sampling schemes.

@article{Yin2016ImprovedNE,
  title={Improved nonparametric estimation of the optimal diagnostic cut-off point associated with the Youden index under different sampling schemes.},
  author={Jingjing Yin and Hani M. Samawi and Daniel Linder},
  journal={Biometrical journal. Biometrische Zeitschrift},
  year={2016},
  volume={58 4},
  pages={915-34}
}
A diagnostic cut-off point of a biomarker measurement is needed for classifying a random subject to be either diseased or healthy. However, the cut-off point is usually unknown and needs to be estimated by some optimization criteria. One important criterion is the Youden index, which has been widely adopted in practice. The Youden index, which is defined as the maximum of (sensitivity + specificity -1), directly measures the largest total diagnostic accuracy a biomarker can achieve. Therefore… CONTINUE READING