Improved network-based identification of protein orthologs

  title={Improved network-based identification of protein orthologs},
  author={Nir Yosef and Roded Sharan and William Stafford Noble},
  volume={24 16},
MOTIVATION Identifying protein orthologs is an important task that is receiving growing attention in the bioinformatics literature. Orthology detection provides a fundamental tool towards understanding protein evolution, predicting protein functions and interactions, aligning protein-protein interaction (PPI) networks of different species and detecting conserved modules within these networks. RESULTS Here, we present a novel diffusion-based framework that builds on the Rankprop algorithm for… CONTINUE READING
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