Improved neovascularization and wound repair by targeting human basic fibroblast growth factor (bFGF) to fibrin

@article{Zhao2008ImprovedNA,
  title={Improved neovascularization and wound repair by targeting human basic fibroblast growth factor (bFGF) to fibrin},
  author={Wenxue Zhao and Qianqian Han and Hang Lin and Yuan Gao and Wenjie Sun and Yannan Zhao and Bin Wang and Bing Chen and Zhifeng Xiao and Jianwu Dai},
  journal={Journal of Molecular Medicine},
  year={2008},
  volume={86},
  pages={1127-1138}
}
Targeted therapy is a new generation of therapeutics, where two critical factors are involved. One is the particular molecular target, and the other is the specific target-binding drug. In this work, the fibrin, a main component of plasma clot at wound sites, was used as the target for human bFGF, aiming to improve therapeutic neovascularization and wound repair. To endow bFGF with fibrin-targeting ability, a fibrin-binding peptide Kringle1 (K1), derived from human plasminogen, was fused to… CONTINUE READING
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