Improved myocardial perfusion in chronic diabetic mice by the up-regulation of pLKB1 and AMPK signaling.


Previous studies related impaired myocardial microcirculation in diabetes to oxidative stress and endothelial dysfunction. Thus, this study was aimed to determine the effect of up-regulating pAMPK-pAKT signaling on coronary microvascular reactivity in the isolated heart of diabetic mice. We measured coronary resistance in wild-type and streptozotocin (STZ… (More)
DOI: 10.1002/jcb.22486


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