Improved method for the determination of kynurenic acid in rat plasma by column-switching HPLC with post-column fluorescence detection

@inproceedings{Mitsuhashi2006ImprovedMF,
  title={Improved method for the determination of kynurenic acid in rat plasma by column-switching HPLC with post-column fluorescence detection},
  author={Shigenobu Mitsuhashi and Takanori Fukushima and Junko Kawai and Masayuki Tomiya and Tomofumi Santa and Kazuhiro Imai and Toshimasa Toyo’oka},
  year={2006}
}
Abstract Kynurenic acid (KYNA), an endogenous antagonist of ionotropic glutamate and α7 nicotinic receptors, was fluorometrically determined by column-switching high-performance liquid chromatography (HPLC) with fluorescence detection. The HPLC system consists of two octadecyl silica (ODS) columns, both of which are connected with an anion-exchange column (trapping column). Following sample injection onto the HPLC column, KYNA was separated on the first ODS column with a mobile phase of H 2 O… CONTINUE READING

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