Improved method for determining partition and diffusion coefficients in human dermis.

@article{Ibrahim2010ImprovedMF,
  title={Improved method for determining partition and diffusion coefficients in human dermis.},
  author={Rania Elsayed Ibrahim and Gerald B Kasting},
  journal={Journal of pharmaceutical sciences},
  year={2010},
  volume={99 12},
  pages={
          4928-39
        }
}
Accurate values of partition and diffusion coefficients within the lower skin layers are among the information required to estimate skin concentrations of permeants following topical application. For highly lipophilic compounds these parameters also play a significant role in determining systemic absorption rates. In this study methodology is described for making more accurate in vitro measurements of partition and diffusion coefficients in dermis. Isolated human dermis obtained from surgical… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Improved Estimation of Transport Parameters in the Dermis

VIEW 9 EXCERPTS
CITES RESULTS, BACKGROUND & METHODS
HIGHLY INFLUENCED

Similar Papers

Loading similar papers…