Improved metabolic control by Ipomoea batatas (Caiapo) is associated with increased adiponectin and decreased fibrinogen levels in type 2 diabetic subjects

  title={Improved metabolic control by Ipomoea batatas (Caiapo) is associated with increased adiponectin and decreased fibrinogen levels in type 2 diabetic subjects},
  author={Bernhard Ludvik and Markolf Hanefeld and Giovanni Pacini},
Aim:  The extract of the white‐skinned sweet potato Ipomoea batatas (Caiapo) has been shown to ameliorate glucose control by improving insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). The present study was designed to further evaluate its mode of action on insulin sensitivity over an extended period of time as well as the effects on fibrinogen and other markers of low‐grade inflammation. 
The Effects of an Arabinogalactan-Protein from the White-Skinned Sweet Potato (Ipomoea batatas L.) on Blood Glucose in Spontaneous Diabetic Mice
The effects of an arabinogalactanprotein (WSSP-AGP) from Ipomoea batatas L. on hyperglycemia in db/db mice suggests that amelioration of insulin resistance by WSSP- AGP causes to lead its hypoglycemic effects.
Targeting Metabolic Consequences of Insulin Resistance in Polycystic Ovary Syndrome by D-chiro-inositol and Emerging Nutraceuticals: A Focused Review
D-chiro-inositol (DCI), which is a naturally occurring stereoisomer of inositol, has been classified as an insulin-sensitizer and seems to mitigate multiple InsR-related metabolic alterations in PCOS with a safe profile, and according to a multi-targeted design, the supplementation with DCI can be synergistically integrated by combining other potential insulin-magnifying drugs and/or nutraceuticals.
Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review
The intake of ANT-rich supplements should be considered due to their plausible ability for prevention and management of MetS, and randomized double-blind clinical trials are obligatory for evaluating the bioefficacy and pharmacological mechanisms of ANTs and their pharmaceutical formulations in patients with MetS.
The Benefit of Purple Aruk Rice (Siangu) in Lowering Body Mass Index (BMI) and Body Fat Percentage
Organoleptic assessment showed that the aroma of PAR is dislikeable but the natural purple colour is likeable and consumption of aruk purple rice lower BMI and body fat percentage more effective than consumption of plain rice.
Hypoglycemic herbs and their action mechanisms
This article reviews recent findings about some of the most popular hypoglycemic herbs, such as ginseng, bitter melon and Coptis chinensis, and discusses their popular commercially available herbal preparations.
White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice
WSP has antihyperglycemic effects by inducing pancreatic islet regeneration and insulin resistance amelioration and has potential applications in dietary diabetes management.
Sweet potato (Ipomoea batatas) attenuates diet-induced aortic stiffening independent of changes in body composition.
It is shown that sweet potato attenuates diet-induced aortic stiffness independent of body mass and composition, which is associated with a normalization of arterial oxidative stress possibly due to mitochondrial uncoupling.
Sweet potato for type 2 diabetes mellitus.
There is insufficient evidence about the use of sweet potato for type 2 diabetes mellitus, and issues of standardization and quality control of preparations - including other varieties ofsweet potato - need to be addressed.
Phytotherapy in diabetes: Review on potential mechanistic perspectives.
A comprehensive review on the available antidiabetic plants that have been approved by pharmacological and clinical evaluations, and which their mechanism(s) of action is assured, is provided.
Evaluation of white sweet potato tube-feeding formula in elderly diabetic patients: a randomized controlled trial
WSP incorporated into enteral formulas can improve nutrition status and glycemic control in elderly diabetic patients, according to the results of a pilot clinical trial in long-term care institutions.


The effect of Ipomoea batatas (Caiapo) on glucose metabolism and serum cholesterol in patients with type 2 diabetes: a randomized study.
The aim of this study was to assess the effect of caiapo on glucose metabolism and its tolerability and mode of action in male Caucasian type 2 diabetic patients in a randomized, double-blind prospective study in parallel groups controlled with placebo.
Efficacy of Ipomoea batatas (Caiapo) on diabetes control in type 2 diabetic subjects treated with diet.
The long-term efficacy of Caiapo on glucose control was demonstrated by the observed decrease in HbA(1c) for the first time, and the neutraceutical Caiapa seems to be a useful agent in the treatment of type 2 diabetes.
Treatment of insulin resistance with peroxisome proliferator–activated receptor γ agonists
Type 2 diabetes only develops in the context of insulin resistance plus β cell dysfunction, and most epidemiologic studies have indicated that in the early, prediabetic state, insulin resistance is the antecedent abnormality.
Isolation of Antidiabetic Components from White-Skinned Sweet Potato (Ipomoea batatas L.)
The antidiabetic component was not eliminated during dialysis and was soluble in 85% ethanol and 15% TCA, but it passed through a filter that allos the passage of substance of a molescular weight of 30,000.
Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression.
The data suggest that pioglitazone increases plasma adiponectin levels by posttranscriptional regulation in contrast to transcriptional regulation of adiponECTin in relation to insulin sensitivity in NGT vs. IGT subjects.
Methods for clinical assessment of insulin sensitivity and beta-cell function.
  • G. Pacini, A. Mari
  • Medicine
    Best practice & research. Clinical endocrinology & metabolism
  • 2003
The most relevant experimental tests and data analysis methods for assessing both IS and BCF are described and their characteristic features discussed to help investigators choose the most suitable test for their needs.
Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome
It is concluded that insulin sensitivity, glucose tolerance, blood pressure, body fat mass and distribution, and serum lipids are a network of mutually interrelated functions and an insulin resistance syndrome underlies each and all of the six disorders carrying an increased risk of coronary artery disease.