Improved measurement of low-density-lipoprotein susceptibility to copper-induced oxidation: application of a short procedure for isolating low-density lipoprotein.

@article{Kleinveld1992ImprovedMO,
  title={Improved measurement of low-density-lipoprotein susceptibility to copper-induced oxidation: application of a short procedure for isolating low-density lipoprotein.},
  author={Henne A Kleinveld and Heidi L. M. Hak-Lemmers and Anton F. H. Stalenhoef and Pierre N. M. Demacker},
  journal={Clinical chemistry},
  year={1992},
  volume={38 10},
  pages={2066-72}
}
Low-density-lipoprotein (LDL) oxidation may provide the crucial link between plasma LDL and atherosclerotic-lesion formation. Oxidation can be induced in vitro by incubating LDL with cells or metal ions and can be measured by continuously monitoring conjugated-diene absorbance at 234 nm. Measurement of LDL oxidizability was improved by performing the assay with 0.05 g of LDL-protein per liter of phosphate buffer containing 1 mumol of EDTA, by initiating oxidation by adding CuCl2 (5 mumol/L) at… CONTINUE READING

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