Improved lycopene production by Blakeslea trispora with isopentenyl compounds and metabolic precursors

@article{Shi2011ImprovedLP,
  title={Improved lycopene production by Blakeslea trispora with isopentenyl compounds and metabolic precursors},
  author={Yan-qiu Shi and Xiuqing Xin and Q. Yuan},
  journal={Biotechnology Letters},
  year={2011},
  volume={34},
  pages={849-852}
}
The highest lycopene production in mated cultures of Blakeslea trispora was 578 mg/l by adding 42 mg geraniol/l to the medium after 48 h of growth. The control gave 317 mg/l. Adding isopentenyl alcohol at 40 mg/l, mevalonic acid at 17.5 mg/l or dimethyl allyl alcohol at 150 mg, each after 36 h growth, gave lycopene yields 62, 45 and 47%, respectively, higher than the control. 
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Cyclase inhibitor tripropylamine significantly enhanced lycopene accumulation in Blakeslea trispora.
Biotechnological production of lycopene by microorganisms.
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