Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy.

@article{Boekhoorn2006ImprovedLP,
  title={Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy.},
  author={Karin Boekhoorn and Dick Terwel and Barbara Biemans and Peter Borghgraef and Olof Wiegert and Ger J. A. Ramakers and Koos de Vos and Harm J. Krugers and Takami Tomiyama and Hiroshi Mori and Marian Joels and Fred van Leuven and Paul John Lucassen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 13},
  pages={3514-23}
}
The microtubule binding protein tau is implicated in neurodegenerative tauopathies, including frontotemporal dementia (FTD) with Parkinsonism caused by diverse mutations in the tau gene. Hyperphosphorylation of tau is considered crucial in the age-related formation of neurofibrillary tangles (NFTs) correlating well with neurotoxicity and cognitive defects. Transgenic mice expressing FTD mutant tau-P301L recapitulate the human pathology with progressive neuronal impairment and accumulation of… CONTINUE READING

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