Improved linear mixed models for genome-wide association studies

@article{Listgarten2012ImprovedLM,
  title={Improved linear mixed models for genome-wide association studies},
  author={Jennifer Listgarten and Christoph Lippert and Carl Myers Kadie and Robert I. Davidson and Eleazar Eskin and David Heckerman},
  journal={Nature Methods},
  year={2012},
  volume={9},
  pages={525-526}
}
to determine these similarities1. Here, however, we show theoretically and experimentally that carefully selecting a small number of SNPs systematically increases power (that is, it jointly reduces false positives and false negatives), improves calibration (lessens inflation or deflation of the test statistic) and reduces computational cost. Our approach is motivated by two considerations. First, an LMM with no fixed effects using genetic similarities constructed from a set of SNPs is… CONTINUE READING
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