Improved labelling of DTPA- and DOTA- conjugated peptides and antibodies with In in HEPES and MES buffer

Abstract

Background: In single photon emission computed tomography [SPECT], high specific activity of In-labelled tracers will allow administration of low amounts of tracer to prevent receptor saturation and/or side effects. To increase the specific activity, we studied the effect of the buffer used during the labelling procedure: NaAc, NH4Ac, HEPES and MES buffer… (More)

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