Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat.

@article{Tikellis2004ImprovedIM,
  title={Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat.},
  author={Christos Tikellis and Peter J Wookey and Riccardo Candido and Sof Andrikopoulos and Merlin C Thomas and Mark Cooper},
  journal={Diabetes},
  year={2004},
  volume={53 4},
  pages={
          989-97
        }
}
The renin-angiotensin system (RAS) has an important role in the endocrine pancreas. Although angiotensin II has significant effects on cell proliferation and apoptosis, the contribution of the RAS to changes in islet structure and function associated with type 2 diabetes is yet to be defined. This study examined the specific effects of RAS blockade on islet structure and function in diabetes. Thirty-six male Zucker diabetic fatty (ZDF) rats, 10 weeks of age, were randomized to receive the… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 57 REFERENCES

Angiotensin II induces apoptosis in renal proximal tubular cells.

  • American journal of physiology. Renal physiology
  • 2003
VIEW 3 EXCERPTS

Increased islet apoptosis in Pdx1+/- mice.

  • The Journal of clinical investigation
  • 2003
VIEW 3 EXCERPTS