Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice.

@article{Longo2008ImprovedIS,
  title={Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice.},
  author={Kenneth A. Longo and Soratree Charoenthongtrakul and Derek J Giuliana and Elizabeth K Govek and Thomas McDonagh and Yong Qi and Peter S Distefano and Brad J. Geddes},
  journal={Regulatory peptides},
  year={2008},
  volume={150 1-3},
  pages={55-61}
}
Stimulation of the ghrelin receptor (GhrR) by ghrelin results in a variety of metabolic changes including increased food intake, fat storage and insulin resistance. Loss of ghrelin signaling is protective against diet-induced obesity, suggesting that ghrelin plays a significant homeostatic role in conditions of metabolic stress. We examined glycemic control in GhrR -/- mice fed a high-fat diet, and used indirect calorimetry to assess fuel substrate usage and energy expenditure. GhrR -/- mice… CONTINUE READING

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