Improved insulin sensitivity and adipose tissue dysregulation after short-term treatment with pioglitazone in non-diabetic, insulin-resistant subjects

@article{Hammarstedt2004ImprovedIS,
  title={Improved insulin sensitivity and adipose tissue dysregulation after short-term treatment with pioglitazone in non-diabetic, insulin-resistant subjects},
  author={Ann Hammarstedt and Victoria Rotter Sopasakis and Silvia Gogg and P.-A. Jansson and Ulf Smith},
  journal={Diabetologia},
  year={2004},
  volume={48},
  pages={96-104}
}
We examined whether short-term treatment with a thiazolidinedione improves insulin sensitivity in non-obese but insulin-resistant subjects and whether this is associated with an improvement in dysregulated adipose tissue (reduced expression of IRS-1, GLUT4, PPARγ co-activator 1 and markers of terminal differentiation) that we have previously documented to be associated with insulin resistance. Ten non-diabetic subjects, identified as having low IRS-1 and GLUT-4 protein in adipose cells as… CONTINUE READING