Improved innate immunity of endotoxin-tolerant mice increases resistance to Salmonella enterica serovar typhimurium infection despite attenuated cytokine response.

@article{Lehner2001ImprovedII,
  title={Improved innate immunity of endotoxin-tolerant mice increases resistance to Salmonella enterica serovar typhimurium infection despite attenuated cytokine response.},
  author={Martin Dominik Lehner and Jochen R Ittner and Daniela S. Bundschuh and Nico van Rooijen and A Wendel and Thomas Hartung},
  journal={Infection and immunity},
  year={2001},
  volume={69 1},
  pages={463-71}
}
During infection with gram-negative bacteria, exposure of immune cells to lipopolysaccharide (LPS) from the bacterial cell membrane induces a rapid cytokine response which is essential for the activation of host defenses against the invading pathogens. Administration of LPS to mice induces a state of hyporesponsiveness, or tolerance, characterized by reduced cytokine production upon subsequent LPS challenge. In the model of experimental Salmonella enterica serovar Typhimurium infection of mice… CONTINUE READING