Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide.

Abstract

In the present study, andrographolide (Andro, 1) derivatives were screened to identify potent inhibitors against tumor-cell migration and invasion, and associated structure-activity relationships were studied. Compared to 1, compounds 8a-8d exhibited more potent activities against migration in SGC-7901, PC-3, A549, HT-29 and Ec109 cell lines. Improved activities against tumor-cell migration and invasion were proved to be associated with the down-regulation of MMPs.

DOI: 10.1016/j.bmcl.2013.09.049

Cite this paper

@article{Wu2013ImprovedIA, title={Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide.}, author={Zhen-Wei Wu and Hai-wei Xu and Guifu Dai and Meng-Jiao Liu and Li-Ping Zhu and Jian Wu and Ya-Nan Wang and Feng-juan Wu and Dan Zhao and Ming-Fu Gao and Shan-Shan Nie and Wei Han and Jing-hui Song and Hong-min Liu}, journal={Bioorganic & medicinal chemistry letters}, year={2013}, volume={23 23}, pages={6421-6} }