Corpus ID: 236428792

Improved inference for vaccine-induced immune responses via shape-constrained methods

@inproceedings{Laha2021ImprovedIF,
  title={Improved inference for vaccine-induced immune responses via shape-constrained methods},
  author={Nilanjana Laha and Zoe Moodie and Ying Huang and Alexander Luedtke},
  year={2021}
}
We study the performance of shape-constrained methods for evaluating immune response profiles from early-phase vaccine trials. The motivating problem for this work involves quantifying and comparing the IgG binding immune responses to the first and second variable loops (V1V2 region) arising in HVTN 097 and HVTN 100 HIV vaccine trials. We consider unimodal and log-concave shape-constrained methods to compare the immune profiles of the two vaccines, which is reasonable because the data support… Expand

References

SHOWING 1-10 OF 88 REFERENCES
Immune-correlates analysis of an HIV-1 vaccine efficacy trial.
TLDR
V vaccines that are designed to induce higher levels of V1V2 antibodies and lower levels of Env-specific IgA antibodies than are induced by the RV144 vaccine may have improved efficacy against HIV-1 infection. Expand
Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa
TLDR
Results indicate that the RV144 regimen or others like it could be protective in areas where HIV is endemic, and cross-clade immune responses associated with protection were better than expected in South Africa, suggesting wider applicability of this regimen. Expand
Editorial: Special Issue on “Nonparametric Inference Under Shape Constraints”
Shape-constrained inference usually refers to nonparametric function estimation and uncertainty quantification under qualitative shape restrictions such as monotonicity, convexity, log-concavity andExpand
Subtype C ALVAC-HIV and bivalent subtype C gp120/MF59 HIV-1 vaccine in low-risk, HIV-uninfected, South African adults: a phase 1/2 trial
TLDR
The IgG response to the HVTN 100 vaccine was lower than that reported in RV144, but it exceeded the predicted 63% threshold needed for 50% vaccine efficacy using a V1V2 correlate of protection model, and qualified for phase 2b/3 efficacy testing. Expand
Two‐Sample Test Against One‐Sided Alternatives
.  This paper proposes, implements and investigates a new non-parametric two-sample test for detecting stochastic dominance. We pose the question of detecting the stochastic dominance in aExpand
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand.
TLDR
This ALVAC-HIV and AIDSVAX B/E vaccine regimen may reduce the risk of HIV infection in a community-based population with largely heterosexual risk and offer insight for future research. Expand
Benchmarks for detecting ‘breakthroughs’ in clinical trials: empirical assessment of the probability of large treatment effects using kernel density estimation
TLDR
To understand how often ‘breakthroughs,’ that is, treatments that significantly improve health outcomes, can be developed, the probability density function for observed treatment effects from five publicly funded cohorts and one privately funded group is applied. Expand
Detecting the Presence of Mixing with Multiscale Maximum Likelihood
A test of homogeneity tries to decide whether observations come from a single distribution or from a mixture of several distributions. A powerful theory has been developed for the case where theExpand
On Efficiency of the Plug-in Principle for Estimating Smooth Integrated Functionals of a Nonincreasing Density
We consider the problem of estimating smooth integrated functionals of a monotone nonincreasing density $f$ on $[0,\infty)$ using the nonparametric maximum likelihood based plug-in estimator. We findExpand
Weak convergence of the least concave majorant of estimators for a concave distribution function
We study the asymptotic behavior of the least concave majorant of an estimator of a concave distribution function under general conditions. The true concave distribution function is permitted toExpand
...
1
2
3
4
5
...