Corpus ID: 236428792

Improved inference for vaccine-induced immune responses via shape-constrained methods

  title={Improved inference for vaccine-induced immune responses via shape-constrained methods},
  author={Nilanjana Laha and Zoe Moodie and Ying Huang and Alexander Luedtke},
We study the performance of shape-constrained methods for evaluating immune response profiles from early-phase vaccine trials. The motivating problem for this work involves quantifying and comparing the IgG binding immune responses to the first and second variable loops (V1V2 region) arising in HVTN 097 and HVTN 100 HIV vaccine trials. We consider unimodal and log-concave shape-constrained methods to compare the immune profiles of the two vaccines, which is reasonable because the data support… Expand


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