Improved indicators of cell membrane potential that use fluorescence resonance energy transfer.

@article{Gonzlez1997ImprovedIO,
  title={Improved indicators of cell membrane potential that use fluorescence resonance energy transfer.},
  author={Jos{\'e} E. Gonz{\'a}lez and Roger Tsien},
  journal={Chemistry & biology},
  year={1997},
  volume={4 4},
  pages={269-77}
}
BACKGROUND Fluorescence detection of cell membrane potentials is an important technique in neurobiology, cell physiology and pharmaceutical screening, but traditional one-fluorophore indicators either respond too slowly or have limited sensitivity. Recently, we introduced two-component sensors based on the transfer of fluorescence resonance energy from fluorescent lectins bound on one side of the plasma membrane to highly fluorescent oxonol acceptors that electrophorese from one face of the… CONTINUE READING
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