Improved image analysis workflow for 2‐D gels enables large‐scale 2‐D gel‐based proteomics studies – COPD biomarker discovery study

@article{Bandow2008ImprovedIA,
  title={Improved image analysis workflow for 2‐D gels enables large‐scale 2‐D gel‐based proteomics studies – COPD biomarker discovery study},
  author={J. Bandow and J. D. Baker and M. Berth and C. Painter and O. J. Sep{\'u}lveda and K. Clark and I. Kilty and R. Vanbogelen},
  journal={PROTEOMICS},
  year={2008},
  volume={8}
}
  • J. Bandow, J. D. Baker, +5 authors R. Vanbogelen
  • Published 2008
  • Medicine
  • PROTEOMICS
  • 2‐D gel electrophoresis has been used for more than three decades to study the protein complement of organisms, tissues, and cells. Three issues are holding back large‐scale proteomics studies: low‐throughput, high technical variation, and study designs lacking statistical power. We identified image analysis as the central factor connecting these three issues. By developing an improved image analysis workflow we shortened project timelines, decreased technical variation, and thus enabled large… CONTINUE READING
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