Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors.

@article{Nickerson2008ImprovedIO,
  title={Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors.},
  author={Michael L. Nickerson and Erich Jaeger and Yangu Shi and Jeffrey A Durocher and Sunil Mahurkar and David G. Zaridze and Vsevolod Matveev and Vladim{\'i}r Janout and Hellena Kollarova and Vladim{\'i}r Bencko and Marie Navratilova and Neonilia Szeszenia-Dabrowska and Dana Mateş and Anush Mukeria and Ivana Holc{\'a}tov{\'a} and Laura S. Schmidt and Jorge R. Toro and Sara Karami and Rayjean J Hung and G. F. Gerard and W. Marston Linehan and Mar{\'i}a Merino and Berton Zbar and Paolo Boffetta and Paul Brennan and Nathaniel Rothman and Wong-Ho Chow and Frederic M. Waldman and Lee E. Moore},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 15},
  pages={4726-34}
}
PURPOSE To provide a comprehensive, thorough analysis of somatic mutation and promoter hypermethylation of the von Hippel-Lindau (VHL) gene in the cancer genome, unique to clear cell renal cancer (ccRCC). Identify relationships between the prevalence of VHL gene alterations and alteration subtypes with patient and tumor characteristics. EXPERIMENTAL… CONTINUE READING