Improved human bioavailability of vemurafenib, a practically insoluble drug, using an amorphous polymer-stabilized solid dispersion prepared by a solvent-controlled coprecipitation process.

@article{Shah2013ImprovedHB,
  title={Improved human bioavailability of vemurafenib, a practically insoluble drug, using an amorphous polymer-stabilized solid dispersion prepared by a solvent-controlled coprecipitation process.},
  author={Navnit H. Shah and Raman Mahadevan Iyer and Hans-Juergen Mair and Duk Soon Choi and Hung Tian and Ralph Diodone and Karsten F{\"a}hnrich and Anni Pabst-Ravot and Kin Fai Tang and Emmanuel Scheubel and Joseph F. Grippo and Sebastian A Moreira and Zenaida Go and James Mouskountakis and Theresa Louie and Prabha N. Ibrahim and Harpreet Sandhu and Linda Rubia and Hitesh P. Chokshi and Dharmendra Singhal and Waseem A. Malick},
  journal={Journal of pharmaceutical sciences},
  year={2013},
  volume={102 3},
  pages={967-81}
}
The present work deals with improving the solubility of vemurafenib, a practically insoluble drug, by converting it into an amorphous-solid dispersion using a solvent-controlled precipitation process. The dispersion containing vemurafenib and hypromellose acetate succinate (HPMCAS), an enteric polymer, is termed microprecipitated bulk powder (MBP), in which the drug is uniformly dispersed within the polymeric substrate. HPMCAS was found to be the most suitable polymer for vemurafenib MBP, among… CONTINUE READING

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