Improved high-affinity monoclonal antibody to iododeoxyuridine.

  title={Improved high-affinity monoclonal antibody to iododeoxyuridine.},
  author={Marty Vanderlaan and Bruce E. Watkins and Craig Thomas and Frank Dolbeare and Larry H. Stanker},
  volume={7 6},
Three monoclonal antibodies (Mabs), IU-1, IU-4, and B-44 were evaluated in enzyme immunoassays (ELISA) and by flow cytometry for their abilities to recognize bromodeoxyuridine (BrdUrd)- and iododeoxyuridine (IdUrd)-substituted DNA's, nucleotides, and nucleosides. IU-4 is a new Mab, derived from mice immunized with 5-iodo-2'-deoxyuridine-5'-monophosphate (IdUMP) conjugated (IdUMP) conjugated through the phosphate group to albumin. This immunogen was selected to resemble IdUMP in DNA. In… CONTINUE READING

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