Improved herpes simplex virus type 1 amplicon vectors for proportional coexpression of positron emission tomography marker and therapeutic genes.

@article{Jacobs2003ImprovedHS,
  title={Improved herpes simplex virus type 1 amplicon vectors for proportional coexpression of positron emission tomography marker and therapeutic genes.},
  author={Andreas H. Jacobs and Alexandra Winkeler and Markus Hartung and M. M. W. Slack and Claus Dittmar and Christiane Kummer and Christoph Knoess and Norbert Galldiks and S. Vollmar and Klaus Wienhard and Wolf-Dieter Heiss},
  journal={Human gene therapy},
  year={2003},
  volume={14 3},
  pages={277-97}
}
For the development of efficient and safe gene therapy protocols for clinical application it is desirable to determine the tissue dose of vector-mediated therapeutic gene expression noninvasively in vivo. The herpes simplex virus type 1 thymidine kinase gene (HSV-1-tk) has been shown to function as a marker gene for the direct noninvasive in vivo localization of thymidine kinase (TK) expression by positron emission tomography (PET). Using bicistronic or multicistronic gene-expressing cassettes… CONTINUE READING

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