Improved group contribution parameter set for the application of solubility parameters to melt extrusion.

@article{Just2013ImprovedGC,
  title={Improved group contribution parameter set for the application of solubility parameters to melt extrusion.},
  author={Susann Just and Frank Sievert and Markus Thommes and J{\"o}rg Breitkreutz},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2013},
  volume={85 3 Pt B},
  pages={1191-9}
}
Hot-melt extrusion is gaining importance for the production of amorphous solid solutions; in parallel, predictive tools for estimating drug solubility in polymers are increasingly demanded. The Hansen solubility parameter (SP) approach is well acknowledged for its predictive power of the miscibility of liquids as well as the solubility of some amorphous solids in liquid solvents. By solely using the molecular structure, group contribution (GC) methods allow the calculation of Hansen SPs. The GC… CONTINUE READING