Improved grading of breast adenocarcinomas based on genomic instability.

  title={Improved grading of breast adenocarcinomas based on genomic instability.},
  author={Ulrike Kronenwett and S{\"o}ren Huwendiek and Carin Ostring and Neil Portwood and Uwe Roblick and Yudi Pawitan and Ayodele A. Alaiya and Roland Sennerstam and Anders Zetterberg and Gert Auer},
  journal={Cancer research},
  volume={64 3},
Numerous investigations have shown that in primary breast adenocarcinomas DNA aneuploidy in contrast to DNA diploidy indicates high malignancy potential. On the basis of the study of 104 breast carcinomas, we describe a subtype of aneuploidy, which demonstrates a low degree of malignancy. In image cytometric DNA histograms, this subtype possessed a low percentage (< or = 8.8%) of nonmodal DNA values as measured by the stemline scatter index (SSI), which is defined as sum of the percentage of… CONTINUE READING


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