Improved glucose tolerance in mice receiving intraperitoneal transplantation of normal fat tissue

@article{Konrad2007ImprovedGT,
  title={Improved glucose tolerance in mice receiving intraperitoneal transplantation of normal fat tissue},
  author={Daniel Konrad and Assaf Rudich and Eugen J. Schoenle},
  journal={Diabetologia},
  year={2007},
  volume={50},
  pages={833-839}
}
The association between increased (visceral) fat mass, insulin resistance and type 2 diabetes mellitus is well known. Yet, it is unclear whether the mere increase in intra-abdominal fat mass, or rather functional alterations in fat tissue in obesity contribute to the development of insulin resistance in obese patients. Here we attempted to isolate the metabolic effect of increased fat mass by fat tissue transplantation. Epididymal fat pads were removed from male C57Bl6/J mice and transplanted… CONTINUE READING
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