Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice.

@article{Ahrn2000ImprovedGT,
  title={Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice.},
  author={Bo Ahr{\'e}n and Jens Juul Holst and Hans G. M{\aa}rtensson and Boerk Balkan},
  journal={European journal of pharmacology},
  year={2000},
  volume={404 1-2},
  pages={
          239-45
        }
}
We explored whether inhibition of the enzyme dipeptidyl peptidase IV (DPP IV) increases endogenous levels of glucagon-like peptide-1 (GLP-1) and improves glucose tolerance and insulin secretion in mice. Glucose (150 mg) was administered through a gastric gavage with or without the inhibitor of dipeptidyl peptidase IV, valine-pyrrolidide (100 micromol/kg), in high-fat fed glucose intolerant or control C57BL/6J mice. The increase in plasma GLP-1 after gastric glucose was potentiated by dipeptidyl… CONTINUE READING
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