Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet.

@article{Bjursell2011ImprovedGC,
  title={Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet.},
  author={Mikael Bjursell and Ther{\'e}se Admyre and Melker G{\"o}ransson and Anna E. Marley and David M. Smith and Jan Oscarsson and M Bohlooly-y},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2011},
  volume={300 1},
  pages={
          E211-20
        }
}
Free fatty acid receptor 2 (Ffar2), also known as GPR43, is activated by short-chain fatty acids (SCFA) and expressed in intestine, adipocytes, and immune cells, suggesting involvement in lipid and immune regulation. In the present study, Ffar2-deficient mice (Ffar2-KO) were given a high-fat diet (HFD) or chow diet and studied with respect to lipid and energy metabolism. On a HFD, Ffar2-KO mice had lower body fat mass and increased lean body mass. The changed body composition was accompanied by… 

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