Improved gene transfer into human lymphocytes using retroviruses with the gibbon ape leukemia virus envelope.

@article{Lam1996ImprovedGT,
  title={Improved gene transfer into human lymphocytes using retroviruses with the gibbon ape leukemia virus envelope.},
  author={John S. Lam and Mark E. Reeves and Robin Cowherd and Steven A Rosenberg and Patrick Hwu},
  journal={Human gene therapy},
  year={1996},
  volume={7 12},
  pages={1415-22}
}
Gene-modified lymphocytes have a potential role in the therapy of cancer, infectious diseases, and genetic disorders of the immune system. Current gene therapy protocols involving gene transfer into lymphocytes utilize retroviruses with amphotropic envelope proteins. However, transduction efficiencies in lymphocytes using these viruses are relatively low. A potential strategy to improve gene transfer efficiency is the utilization of alternative retroviral envelopes that target unique receptors… CONTINUE READING

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