Improved free energy parameters for RNA pseudoknotted secondary structure prediction.

@article{Andronescu2010ImprovedFE,
  title={Improved free energy parameters for RNA pseudoknotted secondary structure prediction.},
  author={Mirela S Andronescu and Cristina Pop and Anne E. Condon},
  journal={RNA},
  year={2010},
  volume={16 1},
  pages={26-42}
}
Accurate prediction of RNA pseudoknotted secondary structures from the base sequence is a challenging computational problem. Since prediction algorithms rely on thermodynamic energy models to identify low-energy structures, prediction accuracy relies in large part on the quality of free energy change parameters. In this work, we use our earlier constraint generation and Boltzmann likelihood parameter estimation methods to obtain new energy parameters for two energy models for secondary… CONTINUE READING